MersV1, Main, Exploration, bibRecord, 002177

Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study

Identifieur interne : 002177 ( Main/Exploration ); précédent : 002176; suivant : 002178

Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study

Auteurs : Chantal B. E. M. Reusken [Pays-Bas] ; Bart L. Haagmans [Pays-Bas] ; Marcel A. Müller [Allemagne] ; Carlos Gutierrez [Espagne] ; Gert-Jan Godeke [Pays-Bas] ; Benjamin Meyer [Allemagne] ; Doreen Muth [Allemagne] ; V. Stalin Raj [Pays-Bas] ; Laura Smits-De Vries [Pays-Bas] ; Victor M. Corman [Allemagne] ; Jan-Felix Drexler [Allemagne] ; Saskia L. Smits [Pays-Bas] ; Yasmin E. El Tahir [Oman] ; Rita De Sousa [Pays-Bas, Suède] ; Janko Van Beek [Pays-Bas] ; Norbert Nowotny [Oman, Autriche] ; Kees Van Maanen [Pays-Bas] ; Ezequiel Hidalgo-Hermoso [Chili] ; Berend-Jan Bosch [Pays-Bas] ; Peter Rottier [Pays-Bas] ; Albert Osterhaus [Pays-Bas] ; Christian Gortazar-Schmidt [Espagne] ; Christian Drosten [Allemagne] ; Marion P. G. Koopmans [Pays-Bas]

Source :

Lancet. Infectious diseases : (print) [ 1473-3099 ] ; 2013.

RBID : Pascal:13-0329482

Descripteurs français

KwdFr :
- Animaux, Anticorps antiviraux (sang), Anticorps neutralisants (sang), Bovins (sang), Camélidés du Nouveau Monde (sang), Capra (sang), Chameaux (sang), Coronavirus (), Coronavirus (immunologie), Femelle, Humains, Immunoglobuline G (sang), Mâle, Ovis (sang).
MESH :
- immunologie : Coronavirus.
- sang : Anticorps antiviraux, Anticorps neutralisants, Bovins, Camélidés du Nouveau Monde, Capra, Chameaux, Immunoglobuline G, Ovis.
Pascal (Inist)
- Animaux, Coronavirus, Femelle, Humains, Mâle, Sérum, Anticorps, Etude comparative, Coronavirus, Syndrome respiratoire du Moyen-Orient.

English descriptors

KwdEn :
- Animals, Antibodies, Neutralizing (blood), Antibodies, Viral (blood), Antibody, Camelids, New World (blood), Camelus (blood), Cattle (blood), Comparative study, Coronavirus, Coronavirus (classification), Coronavirus (immunology), Female, Goats (blood), Humans, Immunoglobulin G (blood), Male, Middle East respiratory syndrome, Serum, Sheep (blood).
MESH :
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral, Immunoglobulin G.
- blood : Camelids, New World, Camelus, Cattle, Goats, Sheep.
- classification : Coronavirus.
- immunology : Coronavirus.
- Animals, Female, Humans, Male.

Abstract

Background A new betacoronavirus-Middle East respiratory syndrome coronavirus (MERS-CoV)-has been identified in patients with severe acute respiratory infection. Although related viruses infect bats, molecular clock analyses have been unable to identify direct ancestors of MERS-CoV. Anecdotal exposure histories suggest that patients had been in contact with dromedary camels or goats. We investigated possible animal reservoirs of MERS-CoV by assessing specific serum antibodies in livestock. Methods We took sera from animals in the Middle East (Oman) and from elsewhere (Spain, Netherlands, Chile). Cattle (n=80), sheep (n=40), goats (n=40), dromedary camels (n=155), and various other camelid species (n=34) were tested for specific serum IgG by protein microarray using the receptor-binding S1 subunits of spike proteins of MERS-CoV, severe acute respiratory syndrome coronavirus, and human coronavirus OC43. Results were confirmed by virus neutralisation tests for MERS-CoV and bovine coronavirus. Findings 50 of 50 (100%) sera from Omani camels and 15 of 105 (14%) from Spanish camels had protein-specific antibodies against MERS-CoV spike. Sera from European sheep, goats, cattle, and other camelids had no such antibodies. MERS-CoV neutralising antibody titres varied between 1/320 and 1/2560 for the Omani camel sera and between 1/20 and 1/320 for the Spanish camel sera. There was no evidence for cross-neutralisation by bovine coronavirus antibodies. Interpretation MERS-CoV or a related virus has infected camel populations. Both titres and seroprevalences in sera from different locations in Oman suggest widespread infection. Funding European Union, European Centre For Disease Prevention and Control, Deutsche Forschungsgemeinschaft.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106530

Affiliations:

Le document en format XML

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</author>
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<s3>ESP</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
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<sZ>1 aut.</sZ>
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<country>Pays-Bas</country>
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<author><name sortKey="Meyer, Benjamin" sort="Meyer, Benjamin" uniqKey="Meyer B" first="Benjamin" last="Meyer">Benjamin Meyer</name>
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<author><name sortKey="Muth, Doreen" sort="Muth, Doreen" uniqKey="Muth D" first="Doreen" last="Muth">Doreen Muth</name>
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</inist:fA14>
<country>Allemagne</country>
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</affiliation>
</author>
<author><name sortKey="Stalin Raj, V" sort="Stalin Raj, V" uniqKey="Stalin Raj V" first="V." last="Stalin Raj">V. Stalin Raj</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Viroscience, Erasmus Medical Centre</s1>
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<sZ>2 aut.</sZ>
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<country>Pays-Bas</country>
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</affiliation>
</author>
<author><name sortKey="Smits De Vries, Laura" sort="Smits De Vries, Laura" uniqKey="Smits De Vries L" first="Laura" last="Smits-De Vries">Laura Smits-De Vries</name>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Infectious Diseases and Immunology, Utrecht University, Faculty of Veterinary Medicine</s1>
<s2>Utrecht</s2>
<s3>NLD</s3>
<sZ>9 aut.</sZ>
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<country>Pays-Bas</country>
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</placeName>
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</affiliation>
</author>
<author><name sortKey="Corman, Victor M" sort="Corman, Victor M" uniqKey="Corman V" first="Victor M." last="Corman">Victor M. Corman</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Virology, University of Bonn Medical Centre</s1>
<s2>Bonn</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
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</inist:fA14>
<country>Allemagne</country>
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<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Drexler, Jan Felix" sort="Drexler, Jan Felix" uniqKey="Drexler J" first="Jan-Felix" last="Drexler">Jan-Felix Drexler</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Virology, University of Bonn Medical Centre</s1>
<s2>Bonn</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
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<sZ>10 aut.</sZ>
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<country>Allemagne</country>
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<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smits, Saskia L" sort="Smits, Saskia L" uniqKey="Smits S" first="Saskia L." last="Smits">Saskia L. Smits</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Viroscience, Erasmus Medical Centre</s1>
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<country>Pays-Bas</country>
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</placeName>
</affiliation>
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<sZ>12 aut.</sZ>
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<country>Pays-Bas</country>
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</placeName>
</affiliation>
</author>
<author><name sortKey="El Tahir, Yasmin E" sort="El Tahir, Yasmin E" uniqKey="El Tahir Y" first="Yasmin E." last="El Tahir">Yasmin E. El Tahir</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Animal and Veterinary Sciences, College of Agricultural and Marine Sciences, Sultan Qaboos University</s1>
<s2>Muscat</s2>
<s3>OMN</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Oman</country>
<wicri:noRegion>Muscat</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Sousa, Rita" sort="De Sousa, Rita" uniqKey="De Sousa R" first="Rita" last="De Sousa">Rita De Sousa</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre for Infectious Disease Research, Diagnostics and Screening, Division Virology, National Institute for Public Health and the Environment</s1>
<s2>Bilthoven</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>Bilthoven</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>The European Programme for Public Health Microbiology Training, European Center for Disease Control</s1>
<s2>Stockholm</s2>
<s3>SWE</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Beek, Janko" sort="Van Beek, Janko" uniqKey="Van Beek J" first="Janko" last="Van Beek">Janko Van Beek</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre for Infectious Disease Research, Diagnostics and Screening, Division Virology, National Institute for Public Health and the Environment</s1>
<s2>Bilthoven</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>Bilthoven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nowotny, Norbert" sort="Nowotny, Norbert" uniqKey="Nowotny N" first="Norbert" last="Nowotny">Norbert Nowotny</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University</s1>
<s2>Muscat</s2>
<s3>OMN</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Oman</country>
<wicri:noRegion>Muscat</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Viral Zoonoses, Emerging and Vector-Borne Infections Group, Institute of Virology, University of Veterinary Medicine Vienna</s1>
<s2>Vienna</s2>
<s3>AUT</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Maanen, Kees" sort="Van Maanen, Kees" uniqKey="Van Maanen K" first="Kees" last="Van Maanen">Kees Van Maanen</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Animal Health Service</s1>
<s2>Deventer</s2>
<s3>NLD</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>Animal Health Service</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hidalgo Hermoso, Ezequiel" sort="Hidalgo Hermoso, Ezequiel" uniqKey="Hidalgo Hermoso E" first="Ezequiel" last="Hidalgo-Hermoso">Ezequiel Hidalgo-Hermoso</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Conservation and Research, Parque Zoologico Buin Zoo</s1>
<s2>Buin</s2>
<s3>CHL</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Chili</country>
<wicri:noRegion>Buin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bosch, Berend Jan" sort="Bosch, Berend Jan" uniqKey="Bosch B" first="Berend-Jan" last="Bosch">Berend-Jan Bosch</name>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Infectious Diseases and Immunology, Utrecht University, Faculty of Veterinary Medicine</s1>
<s2>Utrecht</s2>
<s3>NLD</s3>
<sZ>9 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Utrecht</settlement>
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</placeName>
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</affiliation>
</author>
<author><name sortKey="Rottier, Peter" sort="Rottier, Peter" uniqKey="Rottier P" first="Peter" last="Rottier">Peter Rottier</name>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Infectious Diseases and Immunology, Utrecht University, Faculty of Veterinary Medicine</s1>
<s2>Utrecht</s2>
<s3>NLD</s3>
<sZ>9 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
<orgName type="university">Université d'Utrecht</orgName>
</affiliation>
</author>
<author><name sortKey="Osterhaus, Albert" sort="Osterhaus, Albert" uniqKey="Osterhaus A" first="Albert" last="Osterhaus">Albert Osterhaus</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Viroscience, Erasmus Medical Centre</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Viroclinics Biosciences BV</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>12 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gortazar Schmidt, Christian" sort="Gortazar Schmidt, Christian" uniqKey="Gortazar Schmidt C" first="Christian" last="Gortazar-Schmidt">Christian Gortazar-Schmidt</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>SaBio-IREC (CSIC-UCLM-JCCM), Ciudad Real</s1>
<s3>ESP</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>SaBio-IREC (CSIC-UCLM-JCCM), Ciudad Real</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Virology, University of Bonn Medical Centre</s1>
<s2>Bonn</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koopmans, Marion P G" sort="Koopmans, Marion P G" uniqKey="Koopmans M" first="Marion P. G." last="Koopmans">Marion P. G. Koopmans</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre for Infectious Disease Research, Diagnostics and Screening, Division Virology, National Institute for Public Health and the Environment</s1>
<s2>Bilthoven</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>Bilthoven</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Viroscience, Erasmus Medical Centre</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Lancet. Infectious diseases : (print)</title>
<title level="j" type="abbreviated">Lancet. Infect.  dis. : (print)</title>
<idno type="ISSN">1473-3099</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Lancet. Infectious diseases : (print)</title>
<title level="j" type="abbreviated">Lancet. Infect.  dis. : (print)</title>
<idno type="ISSN">1473-3099</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antibodies, Neutralizing (blood)</term>
<term>Antibodies, Viral (blood)</term>
<term>Antibody</term>
<term>Camelids, New World (blood)</term>
<term>Camelus (blood)</term>
<term>Cattle (blood)</term>
<term>Comparative study</term>
<term>Coronavirus</term>
<term>Coronavirus (classification)</term>
<term>Coronavirus (immunology)</term>
<term>Female</term>
<term>Goats (blood)</term>
<term>Humans</term>
<term>Immunoglobulin G (blood)</term>
<term>Male</term>
<term>Middle East respiratory syndrome</term>
<term>Serum</term>
<term>Sheep (blood)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Anticorps antiviraux (sang)</term>
<term>Anticorps neutralisants (sang)</term>
<term>Bovins (sang)</term>
<term>Camélidés du Nouveau Monde (sang)</term>
<term>Capra (sang)</term>
<term>Chameaux (sang)</term>
<term>Coronavirus ()</term>
<term>Coronavirus (immunologie)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunoglobuline G (sang)</term>
<term>Mâle</term>
<term>Ovis (sang)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term>
<term>Antibodies, Viral</term>
<term>Immunoglobulin G</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Camelids, New World</term>
<term>Camelus</term>
<term>Cattle</term>
<term>Goats</term>
<term>Sheep</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Anticorps neutralisants</term>
<term>Bovins</term>
<term>Camélidés du Nouveau Monde</term>
<term>Capra</term>
<term>Chameaux</term>
<term>Immunoglobuline G</term>
<term>Ovis</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term>
<term>Coronavirus</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Sérum</term>
<term>Anticorps</term>
<term>Etude comparative</term>
<term>Coronavirus</term>
<term>Syndrome respiratoire du Moyen-Orient</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background A new betacoronavirus-Middle East respiratory syndrome coronavirus (MERS-CoV)-has been identified in patients with severe acute respiratory infection. Although related viruses infect bats, molecular clock analyses have been unable to identify direct ancestors of MERS-CoV. Anecdotal exposure histories suggest that patients had been in contact with dromedary camels or goats. We investigated possible animal reservoirs of MERS-CoV by assessing specific serum antibodies in livestock. Methods We took sera from animals in the Middle East (Oman) and from elsewhere (Spain, Netherlands, Chile). Cattle (n=80), sheep (n=40), goats (n=40), dromedary camels (n=155), and various other camelid species (n=34) were tested for specific serum IgG by protein microarray using the receptor-binding S1 subunits of spike proteins of MERS-CoV, severe acute respiratory syndrome coronavirus, and human coronavirus OC43. Results were confirmed by virus neutralisation tests for MERS-CoV and bovine coronavirus. Findings 50 of 50 (100%) sera from Omani camels and 15 of 105 (14%) from Spanish camels had protein-specific antibodies against MERS-CoV spike. Sera from European sheep, goats, cattle, and other camelids had no such antibodies. MERS-CoV neutralising antibody titres varied between 1/320 and 1/2560 for the Omani camel sera and between 1/20 and 1/320 for the Spanish camel sera. There was no evidence for cross-neutralisation by bovine coronavirus antibodies. Interpretation MERS-CoV or a related virus has infected camel populations. Both titres and seroprevalences in sera from different locations in Oman suggest widespread infection. Funding European Union, European Centre For Disease Prevention and Control, Deutsche Forschungsgemeinschaft.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Autriche</li>
<li>Chili</li>
<li>Espagne</li>
<li>Oman</li>
<li>Pays-Bas</li>
<li>Suède</li>
</country>
<region><li>District de Cologne</li>
<li>Hollande-Méridionale</li>
<li>Rhénanie-du-Nord-Westphalie</li>
<li>Svealand</li>
<li>Utrecht (province)</li>
<li>Vienne (Autriche)</li>
</region>
<settlement><li>Bonn</li>
<li>Rotterdam</li>
<li>Stockholm</li>
<li>Utrecht</li>
<li>Vienne (Autriche)</li>
</settlement>
<orgName><li>Université d'Utrecht</li>
</orgName>
</list>
<tree><country name="Pays-Bas"><noRegion><name sortKey="Reusken, Chantal B E M" sort="Reusken, Chantal B E M" uniqKey="Reusken C" first="Chantal B. E. M." last="Reusken">Chantal B. E. M. Reusken</name>
</noRegion>
<name sortKey="Bosch, Berend Jan" sort="Bosch, Berend Jan" uniqKey="Bosch B" first="Berend-Jan" last="Bosch">Berend-Jan Bosch</name>
<name sortKey="De Sousa, Rita" sort="De Sousa, Rita" uniqKey="De Sousa R" first="Rita" last="De Sousa">Rita De Sousa</name>
<name sortKey="Godeke, Gert Jan" sort="Godeke, Gert Jan" uniqKey="Godeke G" first="Gert-Jan" last="Godeke">Gert-Jan Godeke</name>
<name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L." last="Haagmans">Bart L. Haagmans</name>
<name sortKey="Koopmans, Marion P G" sort="Koopmans, Marion P G" uniqKey="Koopmans M" first="Marion P. G." last="Koopmans">Marion P. G. Koopmans</name>
<name sortKey="Koopmans, Marion P G" sort="Koopmans, Marion P G" uniqKey="Koopmans M" first="Marion P. G." last="Koopmans">Marion P. G. Koopmans</name>
<name sortKey="Osterhaus, Albert" sort="Osterhaus, Albert" uniqKey="Osterhaus A" first="Albert" last="Osterhaus">Albert Osterhaus</name>
<name sortKey="Osterhaus, Albert" sort="Osterhaus, Albert" uniqKey="Osterhaus A" first="Albert" last="Osterhaus">Albert Osterhaus</name>
<name sortKey="Rottier, Peter" sort="Rottier, Peter" uniqKey="Rottier P" first="Peter" last="Rottier">Peter Rottier</name>
<name sortKey="Smits De Vries, Laura" sort="Smits De Vries, Laura" uniqKey="Smits De Vries L" first="Laura" last="Smits-De Vries">Laura Smits-De Vries</name>
<name sortKey="Smits, Saskia L" sort="Smits, Saskia L" uniqKey="Smits S" first="Saskia L." last="Smits">Saskia L. Smits</name>
<name sortKey="Smits, Saskia L" sort="Smits, Saskia L" uniqKey="Smits S" first="Saskia L." last="Smits">Saskia L. Smits</name>
<name sortKey="Stalin Raj, V" sort="Stalin Raj, V" uniqKey="Stalin Raj V" first="V." last="Stalin Raj">V. Stalin Raj</name>
<name sortKey="Van Beek, Janko" sort="Van Beek, Janko" uniqKey="Van Beek J" first="Janko" last="Van Beek">Janko Van Beek</name>
<name sortKey="Van Maanen, Kees" sort="Van Maanen, Kees" uniqKey="Van Maanen K" first="Kees" last="Van Maanen">Kees Van Maanen</name>
</country>
<country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Muller, Marcel A" sort="Muller, Marcel A" uniqKey="Muller M" first="Marcel A." last="Müller">Marcel A. Müller</name>
</region>
<name sortKey="Corman, Victor M" sort="Corman, Victor M" uniqKey="Corman V" first="Victor M." last="Corman">Victor M. Corman</name>
<name sortKey="Drexler, Jan Felix" sort="Drexler, Jan Felix" uniqKey="Drexler J" first="Jan-Felix" last="Drexler">Jan-Felix Drexler</name>
<name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name>
<name sortKey="Meyer, Benjamin" sort="Meyer, Benjamin" uniqKey="Meyer B" first="Benjamin" last="Meyer">Benjamin Meyer</name>
<name sortKey="Muth, Doreen" sort="Muth, Doreen" uniqKey="Muth D" first="Doreen" last="Muth">Doreen Muth</name>
</country>
<country name="Espagne"><noRegion><name sortKey="Gutierrez, Carlos" sort="Gutierrez, Carlos" uniqKey="Gutierrez C" first="Carlos" last="Gutierrez">Carlos Gutierrez</name>
</noRegion>
<name sortKey="Gortazar Schmidt, Christian" sort="Gortazar Schmidt, Christian" uniqKey="Gortazar Schmidt C" first="Christian" last="Gortazar-Schmidt">Christian Gortazar-Schmidt</name>
</country>
<country name="Oman"><noRegion><name sortKey="El Tahir, Yasmin E" sort="El Tahir, Yasmin E" uniqKey="El Tahir Y" first="Yasmin E." last="El Tahir">Yasmin E. El Tahir</name>
</noRegion>
<name sortKey="Nowotny, Norbert" sort="Nowotny, Norbert" uniqKey="Nowotny N" first="Norbert" last="Nowotny">Norbert Nowotny</name>
</country>
<country name="Suède"><region name="Svealand"><name sortKey="De Sousa, Rita" sort="De Sousa, Rita" uniqKey="De Sousa R" first="Rita" last="De Sousa">Rita De Sousa</name>
</region>
</country>
<country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Nowotny, Norbert" sort="Nowotny, Norbert" uniqKey="Nowotny N" first="Norbert" last="Nowotny">Norbert Nowotny</name>
</region>
</country>
<country name="Chili"><noRegion><name sortKey="Hidalgo Hermoso, Ezequiel" sort="Hidalgo Hermoso, Ezequiel" uniqKey="Hidalgo Hermoso E" first="Ezequiel" last="Hidalgo-Hermoso">Ezequiel Hidalgo-Hermoso</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration MERS

Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study

Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study

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